ABSTRACT Background: Posttraumatic stress disorder (PTSD) occurs following potentially traumatic experiences, but not everyone who experiences trauma develops PTSD. Genetic factors play an important role in shaping how individuals respond to trauma, reflecting gene-environment interaction. An open and important questio...
Jacob Knyspel, S. Kakar, Anna C. Carnegie et al.· European Journal of Psychotr...· 0 citations
Background: Cannabis use disorder (CUD) is an increasingly prevalent substance use disorder among youth. Early initiation, particularly before age 16, significantly increases risk of CUD, psychiatric comorbidity, and adverse psychosocial outcomes. Despite this vulnerability, help-seeking remains low, with only 3% of Ca...
Chloe C. Y. Wong, Oyedegi Ayonrinde· McMaster University Medical...· 0 citations
Findings provide proof-of-concept for the utility of pPGSs in psychiatric research, suggesting both genetic contributions to trauma exposure and GxE effects on psychosis risk, as well as supporting pathway-specific contributions beyond general polygenic risk.
G. Trotta, I. Austin-Zimmerman, E. Spinazzola et al.· Translational Psychiatry· 0 citations
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