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Author

Chloé Savignac

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Open access Jul 2026

Parent-of-origin effects in Alzheimer’s liability dissociate neurocognitive and cardiovascular traits in at-risk individuals

Summary Alzheimer’s disease (AD) has a higher prevalence in women than men and is more frequently inherited from mothers than fathers. Yet, while neuroimaging and biomarker studies link maternal family history to stronger AD-related alterations, epidemiological studies suggest that paternal history confers comparable o...

Chloé Savignac, Frédéric St-Onge, S. Villeneuve et al. · 0 citations
Open access Aug 2026

Mapping Alzheimer’s neuropathology signatures to the whole brain transcriptome using machine learning data-fusion

In Alzheimer’s disease (AD), misfolded proteins emerge across the entire brain in structured, yet not rigid, spatiotemporal patterns. Yet, a systematic bias of single-cell genomics toward sampling mostly cortical tissue limits our understanding of the whole-brain transcriptomic vulnerability to AD. Here, we develop a m...

Anwesha Bhattacharya, Chloé Savignac, Liam Hodgson et al. · 0 citations

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