Author

Chong Wu

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Open access Sep 2026

Mendel, a foundation model of human genetic variation, prioritizes regulatory variants and improves gene expression prediction

Human genome-wide association studies have identified hundreds of thousands of variant trait associations, but interpreting their mechanistic consequences at allele resolution remains a central bottleneck. DNA foundation models pretrained on genomic sequence corpora learn features predictive of regulatory activity, yet...

Arham Salman, Hao-Nan Feng, Peng Wei et al. · bioRxiv · 0 citations

Open access Sep 2026

TigerAI: An AI-powered genetic evidence platform to support clinical development

A novel domain-grounded instruction framework is developed to systematically evaluate GPT-5 for producing genetic evidence relevant to clinical trial success and introduces TigerAI, a dual-purpose platform for AI-powered genetic evidence that benchmarks emerging state-of-the-art LLMs and provides an accessible service...

Zi-Chen Zhang, Wan-Heng Zhang, Xiao-Chen Yang et al. · bioRxiv · 0 citations