Open access
Sep 2026
IL-27 induces a cytotoxic state in CD4+ T cells distinct from the Th1 lineage
CD4+ cytotoxic T lymphocytes (CD4-CTLs) are understudied immune mediators with ambiguous origins. Despite expressing RUNX3, granzyme B (GZMB), and perforin (PRF1), CD4-CTLs are frequently classified as Th1 extensions due to shared interferon-γ (IFNγ) and T-BET expression. Here, we identify interleukin-27 (IL-27) as a i...
M. Matias, R. Marrocco, Kyle Magro et al.
· bioRxiv · 0 citations