Author

Chris R. Harris

2 papers indexed here

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Sep 2026

Abstract A058: UNC5B functions as a metastatic dependency in pancreatic ductal adenocarcinoma through SRC–ZEB1-driven invasion and epithelial-to-mesenchymal transition

Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignancies, with metastatic dissemination representing the principal cause of patient mortality. Despite its clinical significance, the molecular mechanisms governing metastatic competence in PDAC remain incompletely understood. Epithelial-to-mesenchyma...

Muhammad Sadeqi Nezhad, Chris R. Harris, D. Carpizo · Cancer Research · 0 citations

Open access Aug 2026

UNC5B regulates epithelial-to-mesenchymal transition through a SRC-ZEB1 signaling axis to facilitate pancreatic cancer metastasis

UNC5B is identified as a central molecular hub governing metastatic competence in PDAC by promoting EMT and invasion by promoting epithelial-to-mesenchymal transition (EMT) and invasion.

Muhammad Sadeqi Nezhad, Chris R. Harris, O. Prela et al. · Oncogene · 0 citations