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Author

Christian A. Combs

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2 papers indexed here

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Open access Sep 2026

Remodeling of cholesterol metabolism in melanoma progression regulates nuclear membrane mechanics

It is shown that melanoma progression is associated with broad transcriptional remodeling of cholesterol homeostasis that is established early in disease progression, with altered expression of cholesterol biosynthesis genes associated with reduced patient survival.

Michelle A. Baird, Daniela A. Malide, Christian A. Combs et al. · 0 citations
Open access Sep 2026

DVT-primed neutrophils reshape the brain microenvironment to promote brain metastasis

Brain metastasis (BrM) is a devastating complication of triple-negative breast cancer (TNBC), yet how host macroenvironmental conditions influence brain metastatic susceptibility remains poorly understood. Here, we investigated the impact of deep vein thrombosis (DVT), a common complication in patients with cancer, on...

Shunji Endo, Denys Rujchanarong, Karen J. Keeran et al. · 0 citations

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