Author

Christian F. Krebs

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Review Open access Sep 2026

Targeting tissue immune memory in chronic-remitting autoimmune kidney diseases: current concepts and future therapies

ABSTRACT Immune-mediated kidney diseases have a substantial disease burden and frequent disease relapses significantly contribute to the high morbidity. Relapsing disease courses are associated with poor outcome and accelerated progression to end-stage renal disease. The pathomechanisms leading to relapse are diverse a...

Malte Hellmig, Christian F. Krebs · Clinical Kidney Journal · 0 citations

Open access Aug 2026

Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma

It is demonstrated that aberrant Sonic Hedgehog (SHH) signaling during embryonic Choroid Plexus (CP) development triggers a dedifferentiation cascade that reverts mature epithelium to a progenitor-like state and identifies that these tumor cells cultivated in vitro are vulnerable to ATR and CDK inhibition.

Levke-Sophie Peter, L. Altendorf, K. Hack et al. · Acta Neuropathologica Commun... · 0 citations