Selective CB2 receptor activation attenuates neuroinflammation and preserves immune responsiveness after photothrombotic stroke.
Ischemic stroke triggers neuroinflammation that can drive CNS injury-induced immunodepression syndrome (CIDS), a peripheral immunosuppressive state associated with increased infection risk. The endocannabinoid system, particularly cannabinoid receptor type 2 (CB2), represents a promising immunomodulatory target because...