Open access
Oct 2026
Distinct activation mechanisms underlie ligand efficacy at a GPCR
Ligands that bind to the same G protein-coupled receptor (GPCR) can produce widely different levels of signaling. These differences in efficacy are central to pharmacology, yet how a receptor sequence determines signaling level remains incompletely understood. Here we develop a deep mutational pharmacology approach to...
Matthew K. Howard, Eve J. Fine, Karthik Srinivasan et al.
· bioRxiv · 0 citations