Open access
Sep 2026
Modular assembly and property profiling of an expansive, shape-defined library of pentacyclic saturated N-heterocycles
Small-molecule drug discovery is increasingly applied to targets historically classified as “undruggable”, such as non-coding RNAs and biomolecular interactions. These complex interfaces demand ligands with greater three-dimensional complexity and preferred physicochemical profiles that are deficient in typical small m...
E. Boschi, Dmitry Mazunin, Alex Mueller et al.
· Chemical Science · 0 citations