Open access
Sep 2026
Acetyl-CoA–dependent processes are preferentially supported by local metabolite synthesis
The cell nucleus is an active metabolic site. Numerous enzymes best known for their roles in cytosolic or mitochondrial pathways also function in the nucleus, where they contribute to gene regulation and DNA replication and repair. Although metabolites can diffuse through nuclear pores, it remains unclear the extent to...
Julianna G. Supplee, Pedro Costa-Pinheiro, Karl A. Wessendorf-Rodriguez et al.
· Science Advances · 0 citations