Open access
Aug 2026
OTUB1 controls marginal zone B-cell development by stabilizing RelA in a CD40-dependent manner
Ubiquitin-dependent regulation of NF-κB signaling is essential for B-cell homeostasis and fate decisions, yet the contribution of specific deubiquitinating enzymes remains incompletely defined. OTUB1, a lysine-48–specific deubiquitinase, has been broadly implicated in immune regulation, including control of NF-κB signa...
Johannes F. Vogt, Yilang Tang, S. Reissig et al.
· bioRxiv · 0 citations