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Christine M. Minor

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Open access Aug 2026

A two-factor authentication mechanism licenses pilins for pilus assembly in gram-positive bacteria.

A "two-factor authentication" mechanism for pilus assembly in gram-positive bacteria is defined: class C sortases first verify pilin identity by forming a membrane-embedded interface that activates the enzyme, then they recognize the LPXTG motif to initiate loading and crosslinking.

Nicole A. Cheung, Reece M. Pawlaczyk, Brendan J. Mahoney et al. · 0 citations
Open access Feb 2026

AlphaFold-driven structural proteomics reveals extensive cellulosome machinery in human ruminococcal symbionts

It is shown that extensive sequence divergence obscures the detection of many ruminococcal cellulosomes by conventional sequence homology-based methods, and that cellulosomes are far more widespread and structurally diverse in human-associated Ruminococcus species than previously appreciated.

Christine M. Minor, Allen Takayesu, M. Arbing et al. · 0 citations

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