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Author

Christophe Chapard

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Oct 2026

Handles on chromosome architecture.

Cohesin organizes genome folding through loop extrusion, a process regulated by cofactors including NIPBL and PDS5. Recent studies by Wutz et al. and Shah et al. demonstrate that NIPBL promotes loop expansion in mammalian cells, whereas PDS5 restricts loop growth by facilitating NIPBL dissociation from cohesin. Togethe...

Thomas Verin-Debant, Christophe Chapard, Frédéric Beckouet · 0 citations

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