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Author

Christopher A. Polera

2 papers indexed here

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Open access Aug 2026

Discovery and Targeting of a Cryptic Human Proteome

First-in-class therapeutics require first-in-class biology. Yet despite decades of genomic and proteomic cataloging, vast regions of the human transcriptome remain dark and their encoded proteins invisible. Here we present RyboCypher™, an integrated RNA-sequencing and AI-assisted proteogenomics platform that systematic...

J. Chick, Ashley R Woodfin, Jessica Weir et al. · 0 citations
Sep 2026

Abstract IA003: Targeting the antigenic landscape that emerges after KRAS inhibition for PDAC immunotherapy

Pancreatic ductal adenocarcinoma (PDAC) is predicted to emerge as the second leading cause of cancer related death by 2030. Many treatment options that are successful in other cancer types, including immune checkpoint blockade, are generally ineffective in PDAC and the 5-year survival rate has remained stagnant for d...

Alex M. Jaeger, Emma Adhikary, Andrew Deonarine et al. · 0 citations

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