Open access
Sep 2026
Electroconvulsive therapy modulates neurite density and free water in discrete white matter compartments in major depression
Abstract Electroconvulsive therapy (ECT) is the most effective treatment for severe or intractable depression. The disrupt–potentiate–rewire framework proposes that ECT’s therapeutic effects include neural remodeling. We used the neurite orientation dispersion and density imaging (NODDI) model to characterize ECT-relat...
A. Zavaliangos-Petropulu, Paloma Pfeiffer, Madeline Crawford et al.
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