Author

Christopher B. Geyer

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Open access Sep 2026

Sperm development requires TMC5-dependent mechanoresponsive calcium entry

Spermiogenesis, the transformation of round spermatids into streamlined, fertilization-competent sperm, represents cellular morphogenesis at its most extreme1,2. Despite decades of effort, spermiogenesis remains difficult to recapitulate outside the testis2,3, highlighting the importance of cues within the native tissu...

Wenhao Zheng, Lorena Roa-de la Cruz, John Duncan et al. · bioRxiv · 0 citations

Open access Aug 2026

Actin-related ACTL8 localizes to the nucleus and modulates locus-specific transcription through chromatin regulation

It is shown that ACTL8 surprisingly localizes to the nucleus of spermatogonia in human testes and breast and lung cancer cells, and Mechanistically, it is found that ACTL8 interacts with KDM5B, an H3K4 demethylase and transcriptional repressor, and this interaction contributes to changes in migration.

Nuria Cortes-Silva, Sanjana Banerjee, Kristen Dominique Amarillo et al. · bioRxiv · 0 citations