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Christopher Grieg

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Open access Oct 2026

Osteopontin induces cyclo-oxygenase-2 expression in osteoclasts.

Osteopontin (OPN) is a secreted phosphoprotein that is abundant in the bone matrix and plays an important role in bone homeostasis. Cortical bone in OPNnull mice has a heterogenous mineral density and reduced fracture toughness indicative of a defect in bone homeostasis. Osteoclasts binding to bone appears to be mediat...

Christopher Grieg, Hsuan-Ni Lin, J. P. O'Connor · 0 citations

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