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Author

Christopher J. Ward

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Open access Sep 2026

CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD.

Most cases of autosomal dominant polycystic kidney disease (ADPKD) are caused by mutations in PKD1, which reduce polycystin-1 (PC1) levels below a critical functional threshold. Normalizing PC1 dosage mitigates disease progression; therefore, we sought to develop a CRISPR activation (CRISPRa) strategy to transcriptiona...

Anubhav Chakraborty, Meekha M. Varghese, Darren P. Wallace et al. · 0 citations
Open access Aug 2026

Dysregulated Ferritin and Iron Homeostasis in Autosomal Dominant Polycystic Kidney Disease.

Ferritin dysregulation is implicated in numerous pathological conditions, however, its role in autosomal dominant polycystic kidney disease (PKD) remains poorly understood. Ferritin expression is increased in cyst-lining epithelial cells and macrophages in both PKD mouse and human kidneys. To investigate the functional...

Nicole Sommer, Sagine Placide, Elizabeth Weatherly et al. · 0 citations

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