Christopher K. Glass

Cell type-specific histone acetylation landscape in Alzheimer’s disease reveals a putative role of MITF in microglia

Alzheimer’s disease (AD) is characterised by aberrant amyloid beta and tau aggregation, neuroinflammation, demyelination and neurodegeneration, which have been linked to changes in cell-specific gene expression signatures. Among the mechanisms driving cell-type-specific transcriptional changes, histone acetylation play...