Review
Open access
Aug 2026
Inflammatory and Immune Pathways Driving Tumor Necrosis Factor Inhibitor Resistance in Ulcerative Colitis
Abstract Ulcerative colitis (UC) is a chronic immune-mediated inflammatory disease characterized by dysregulated mucosal immunity in genetically susceptible individuals exposed to environmental and microbial triggers. Tumor necrosis factor-alpha (TNF-α) antagonists have transformed the management of moderately-to-sever...
Morgan Fairweather, I. Faggiani, Christopher Ma
· Journal of Inflammation Rese... · 0 citations