Structural modulation of PCL and PCL–PLGA nanoparticles governs physicochemical properties and drug release kinetics
Abstract The semi-crystalline and hydrophobic nature of poly(ε-caprolactone) (PCL) can limit drug release from polymeric nanoparticles (NPs). Strategies such as PCL amorphization and PCL–poly(lactic-co-glycolic acid) (PLGA) blending modify polymer structural organization, but the extent to which these approaches influe...