Open access
Sep 2026
The function of human PIF1 in G quadruplex formation and replication stress response at ALT telomeres
Cancers maintain their telomeres through two telomere maintenance mechanisms: 85-90% of cancers rely on telomerase (TEL+), while 10-15% of cancers adopt the Alternative Lengthening of Telomeres (ALT) pathway. The Break-Induced Replication (BIR) pathway plays a critical role in maintaining telomere length in the ALT+ ce...
A. Ragupathi, Rong-Wei Zhao, Shakir Najit et al.
· bioRxiv · 0 citations