Author

Christopher W. Cairo

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Sep 2026

Synthesis and Application of 3,3-Difluoro Sialic Acid as a Sialyltransferase and Neuraminidase Inhibitor

Sialic acid (Neu5Ac) is a monosaccharide terminating glycoconjugates, serving as ligands for lectins in health and disease. Tools to target sialyltransferases (STs) and neuraminidases (NEUs) are important in the study of sialoglycans. 3FaxNeu5Ac is a common ST inhibitor, while 2,3diFNeu5Ac is a covalent mechanism-bas...

Dhanraj Kumawat, Taylor E. Gray, E. I. Alvarado Melendez et al. · Journal of the American Chem... · 0 citations

Open access Sep 2026

Human NEU3 and NEU4 enzymes prefer short polysialic acid substrates.

Regulation of sialic acids is important to many biological processes and involves both biosynthesis and catabolism. The human neuraminidase enzymes (hNEU) regulate many sialosides in human health and disease. Polysialic acid (polySia) is a polyanion of α(2 → 8) linked sialic acids with roles in nervous, reproductive, a...

Carmanah D. Hunter, Benjamin A. R. Bekkema, Christopher W. Cairo · Carbohydrate Research · 0 citations