Evolution-guided phage therapy for antimicrobial-resistant Acinetobacter baumannii: from resistance evolution and genomic plasticity to receptor-associated fitness trade-offs and clinical translation
Carbapenem-resistant Acinetobacter baumannii (CRAB) is sustained by environmental persistence, genomic plasticity, biofilm-associated tolerance, and rapid adaptation under antibiotic pressure. These features constrain conventional antibiotic regimens and make CRAB a relevant test case for evolution-guided antimicrobial...