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Author

Chuan He

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Open access Sep 2026

Loss of TDP-43 function drives cryptic circular RNAs in neurodegenerative diseases

It is shown that TDP-43 depletion in human neurons induces widespread circRNA changes, especially upregulation of a distinct class of cryptic circRNAs that arise specifically upon loss of TDP-43, and establishes these circRNAs as stable molecular signatures of TDP-43 dysfunction.

Cheng-Zhang Zhu, Zhi-Yan Zhao, Bo-Jun Song et al. · 0 citations
Jul 2026

Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants

It is revealed that the C-terminal IDR of mammalian ALKBH5 anchors its main activity to mRNA, limiting chromatin engagement in mouse embryonic stem cells, and a conserved role for IDRs in restraining chromatin access by RNA and histone demethylases is uncovered.

Liu-Dan Jiang, Long Zhao, Jiang-Bo Wei et al. · 0 citations

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