Author

Chuan-Long Guo

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Oct 2026

Immunotoxicological mechanism of a dual-targeted nanocomposite: Mitochondrial stress-driven cGAS-STING activation in lung cancer.

Lung cancer remains a leading cause of cancer mortality. We developed a dual-targeting nanocomposite FU@TPP/BSA@MnO/UA that induces mitochondrial dysfunction and activates the cGAS-STING pathway. The nanocomposite features a BSA-Mn2 + core, a FU@TPP shell for sequential, dual-stage targeting-first recognizing P-selecti...

Hao-Fan Wang, Cheng-Shuang Wang, Shi-Yu Ma et al. · Colloids and Surfaces B: Bio... · 0 citations

Review Open access Oct 2026

Diosmetin as a Promising Anticancer Agent: Mechanisms, Structural Optimization, and Advanced Delivery Systems

Diosmetin (Dio) is a natural flavonoid with broad-spectrum anticancer activity against various malignancies through mechanisms involving cell cycle arrest, apoptosis induction, metastasis inhibition, and modulation of oncogenic signaling pathways such as STAT3/c-Myc and PI3K/AKT/mTOR; with the exception of CDK2, whic...

Lin Long, Yu-Ning Liu, Jian-Hua Zang et al. · ACS Omega · 0 citations

Sep 2026

Baicalein-loaded rhamnolipid nanomicelles target mitochondrial dysfunction and activate the cGAS-STING pathway for triple-negative breast cancer therapy.

Triple-negative breast cancer (TNBC) remains an intractable malignancy due to the lack of specific therapeutic targets and high metastatic potential. Herein, we fabricated rhamnolipid (RL)-encapsulated baicalein (BAI) nanomicelles (RL/BAI) via a thin-film hydration method. Molecular dynamics (MD) simulations revealed t...

Nan Wang, Shi-Yu Ma, Fang-Yu Jiao et al. · Colloids and Surfaces B: Bio... · 0 citations