Review
Open access
Jul 2026
The lactate–HCAR1 axis in exercise psychiatry: a candidate mechanism linking bone marrow–brain immunity to inflammation-related depression
Exercise is increasingly acknowledged as an effective intervention for depression, yet the biological mechanisms underlying its antidepressant effects remain incompletely defined. Conventional models have emphasized brain-centered pathways, including BDNF signaling, monoaminergic modulation, hypothalamic-pituitary-adre...
Chuankai Luan, Chuanping Lei, Min Liu
· Frontiers in Psychiatry · 0 citations