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Author

Chun-Bo Chen

2 papers indexed here

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Open access Oct 2026

Intestinal 3-methylindole exacerbates sepsis-induced neuroinflammation through microglial NLRP3 inflammasome activation

ABSTRACT Gut microbiota regulates neuroinflammatory responses involved in the pathogenesis of sepsis-associated encephalopathy (SAE). However, the underlying mechanism remains elusive. 16S rRNA sequencing of fecal samples revealed an expansion of the Enterobacteriaceae family in septic mice, and quantitative PCR furthe...

Heng Fang, Si-Min Wu, Pei-Xian Huang et al. · 0 citations
Open access Sep 2026

Peripheral immune phenotyping identifies an immunosuppressed sepsis endotype with potential relevance for immune stratification

Although internally identified immune phenotypes in sepsis provide limited additional prognostic discrimination beyond established severity scores and routine laboratory indicators, they provide valuable insights into immune dysfunction and represent a potential framework for immune stratification.

Rong Luo, Yi-Xia Xie, Xiao-Fang Deng et al. · 0 citations

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