Chun-Guang Miao

Hemodynamic disruption triggers glomerular barrier injury via endothelial glycocalyx degradation in nephrotic syndrome

Nephrotic syndrome (NS) is characterized by heavy proteinuria and is frequently accompanied by a hypercoagulable, hemorheologically abnormal state. Although glomerular filtration barrier (GFB) failure is central to proteinuria, the contribution of altered microhemodynamic cues to endothelial barrier injury remains inco...