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Author

Chun-He Li

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Open access Sep 2026

Learning stochastic dynamics and cell-fate landscapes from single-cell snapshots via optimal transport

The temporal dynamics and stochasticity of gene expression are critical to cell fate decisions, yet integrating snapshot omics data across multiple time points remains a major challenge. Here, we introduce DiffusionOT, a dynamic machine learning framework that infers cellular trajectories from multi–time point single-c...

Jun-Tan Liu, Peijie Zhou, Qing Nie et al. · 0 citations
Sep 2026

RESIDE: Reconstructing Network Interactions and Stochastic Dynamics from Single-Cell Snapshot Expression Data

Deciphering stochastic gene regulatory dynamics and their governing network architectures remains a central challenge in systems biology. While single-cell sequencing advancements have significantly enhanced our understanding of large-scale gene regulatory networks, these snapshot measurements inherently lack temporal...

Xian Chen, Tian-Ci Zhang, Jin-Chao Lv et al. · 0 citations

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