Interleukin-17 orchestrates psoriasis pathogenesis through canonical and noncanonical signaling pathways and emerging therapeutics
A BSTRACT Psoriasis is a chronic immune-mediated skin disorder, characterized by keratinocyte hyperproliferation and inflammatory cell infiltration. The interleukin-23 (IL-23)/IL-17 axis has been established as a central driver of disease pathogenesis, and biologics targeting this pathway has significantly improv...