c-Cbl overexpression alleviates pathological damage in Parkinson's disease by suppressing NLRP3 inflammasome-mediated neuroinflammation via the NF-κB signaling pathway.
Parkinson's disease (PD), the world's second most prevalent neurodegenerative disorder, is characterized by midbrain substantia nigra dopaminergic (DA) neuron loss, neuroinflammation, and α-synuclein aggregation. c-Cbl, a RING-finger E3 ubiquitin ligase highly expressed in the substantia nigra and striatum, regulates n...