IRF8 Transcriptionally Drives NAIP to Promote NLRP3/NLRC4 Inflammasome-Mediated Renal Tubular Pyroptosis in Diabetic Kidney Disease.
OBJECTIVE Renal tubular pyroptosis is a key driver of inflammation and fibrosis in diabetic kidney disease (DKD), yet the contribution of the NAIP-NLRC4 inflammasome arm and its upstream transcriptional control have remained undefined. This study investigated whether NAIP causally promotes tubular pyroptosis in DKD and...