Chun-Li Wang

New small molecular drug approvals for 2025: clinical applications, mechanism of action, and chemical synthesis.

In 2025, the U.S. FDA approved 46 new drug applications, including 34 new molecular entities and 12 biologics license applications. The new molecular entities include 31 small-molecule drugs and 3 oligonucleotides, while the biological license applications cover monoclonal antibodies, bispecific antibodies, antibody-dr...