KIF4A stabilizes TDP43 to promote DNA damage repair and temozolomide resistance in glioblastoma.
Temozolomide (TMZ) resistance remains a major obstacle to effective glioblastoma (GBM) treatment and is closely linked to enhanced DNA damage repair. Kinesin family member 4A (KIF4A) has been implicated in tumor progression, but its role in TMZ resistance remains unclear. In this study, KIF4A and TAR DNA-binding protei...