Open access
Sep 2026
An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines
ABSTRACT The rapid spread of immune‐evasive viral variants, exemplified by SARS‐CoV‐2, highlights the urgent need for broad‐spectrum coronavirus vaccines. Although multimeric display of the receptor‐binding domain (RBD) using exogenous scaffolds improve immune responses, such approaches may elicit off‐target immune res...
Xi-Kui Sun, Junhao Fan, Xiaolu Xie et al.
· Advancement of science · 0 citations