Open access
Aug 2026
DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury
This study investigated how lactylation in histone H3 at lysines 9, 18, and 27 modulates PANoptosis in SA‐AKI and identified DEAD (Asp‐Glu‐Ala‐Asp)‐box helicase 3x (DDX3x), a previously unreported delactylase capable of regulating H3K9/18/27la levels, which influences NINJ1 transcription and PANoptosis.
Hong-Yu Liang, Jihong Jiang, Huan-Xin Yin et al.
· Advancement of science · 0 citations