Chun-Yan Wu

EPG5 orchestrates iron compartmentalization through dual regulation in macroferritinophagy.

Intracellular iron is distributed across functionally distinct pools though the mechanisms regulating its compartmentalization remain unclear. Here we show that EPG5, a tethering factor required for autophagosome-lysosome fusion, governs iron compartmentalization through dual mechanisms: direct involvement in autophagy...