Open access
Oct 2026
The tRNA-Modification Geranyl-2-Thiouridine Enables RNA-Lipid Association.
The packaging of RNA in lipid nanoparticles for protection and delivery was key for the development of mRNA vaccines and therapeutics. Formulation requires the addition of a variety of lipids (including cationic) in high amounts to form complexes with the negatively charged RNA. While this approach was successful for t...
Johannes Singer, Kathrin Halter, Chun-Yin Chan et al.
· Angewandte Chemie · 0 citations