Abstract Objectives To analyse temporal trends, clinical outcomes and healthcare costs of Alzheimer’s disease (AD)-related hospitalisations in Southwest China over 14 years and identify modifiable risk factors for adverse outcomes. Design Retrospective time-series analysis of electronic health records. Setting A tertia...
BACKGROUND
Rare loss-of-function (LoF) variants in Intersectin-1 (ITSN1) have recently been identified as strong genetic risk factors for Parkinson's disease (PD) in individuals of European ancestry.
OBJECTIVE
The aim was to determine whether this association extends to other populations.
METHODS
We analyzed whole-...
Chun-Yu Li, R. Ou, Q. Wei et al.· Movement Disorders· 0 citations
Amyotrophic lateral sclerosis (ALS), the most common type of motor neuron disease, primarily manifests as progressive weakness, atrophy, fasciculations, bulbar palsy, and pyramidal tract symptoms. Accumulating evidence indicates that the pathological spectrum of ALS extends beyond the pyramidal and neuromuscular motor...
Xin-Yao Gao, Ting-Ting Wang, Si-Hui Chen et al.· Frontiers in Genetics· 0 citations
