Open access
Jul 2026
HUWE1 targets mitochondria via RMC1 to promote neurodevelopment.
An AMBRA1-RMC1-HUWE1 signaling axis that directs HUWE1-mediated ubiquitination to mitochondria to regulate neural development is identified and mitochondrial quality-control enhancement as a potential therapeutic strategy is suggested.
Jia-Min Yi, Qin Yang, Chun Zhou et al.
· Proceedings of the National... · 1 citation