Integrative bioinformatic and experimental analyses identify the SPI1-NFE2L2/HMGB1 axis linking pyroptosis and immune dysregulation in non-obstructive azoospermia.
Pyroptosis, a form of inflammatory programmed cell death, has been implicated in the pathogenesis of non-obstructive azoospermia (NOA). However, pyroptosis-related gene function in NOA pathogenesis has yet to be fully characterized. Publicly available datasets were interrogated to pinpoint differentially expressed gene...