Author

Chunlin Wang

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Open access Oct 2026

Colorectal cancer cell-derived arginine drives SMS-mediated spermine synthesis and PI3K-AKT-mTOR-dependent M2 polarization of tumor-associated macrophages

Colorectal cancer (CRC) often exhibits severe tolerance to immunotherapy due to the highly immunosuppressive nature of the tumor microenvironment (TME), with the polarization of tumor-associated macrophages (TAMs) toward the pro-tumor M2 phenotype playing a key role. Arginine (Arg), as a core precursor for the synt...

Qi Wang, Peng-Fei Bi, Chun-Lin Wang et al. · Scientific Reports · 0 citations

Open access Jul 2026

A Multi-omics Regulated Cell Death Framework Defines Immune Phenotypes and Guides Precision Therapy in Colorectal Cancer

It is suggested that RCD-based multi-omics analysis may refine CRC stratification and help generate therapeutic hypotheses, and RCD-associated signatures showed potential for predicting immunotherapy response and survival risk.

Fan Gao, Jun Xiang, Chun-Lin Wang et al. · Translational Oncology · 0 citations