Open access
Jul 2026
The m6A-mediated epi-transcriptomic dysregulation drives synaptic dysfunction in fragile X syndrome.
It is demonstrated that FMRP deficiency drives the aberrant translational upregulation of core m6A writers, a causal relationship definitively validated using CGG-corrected isogenic control lines and suggest a promising avenue for m6A-targeted therapies.
Lu Lu, Avijite Kumer Sarkar, Lan Dao et al.
· Molecular Psychiatry · 0 citations