Open access
Jul 2026
Metabolic-immunoregulatory subtypes reveal prognostic and therapeutic insights in multiple primary lung cancer
This study identified a metabolically distinct malignant epithelial subpopulation enriched in MPLC tumors, characterized by upregulation of amino acid metabolism pathways and active MHC-II-mediated interactions with immunosuppressive CD4+ Treg cells and mast cells.
Yu-Li Zhao, Han-Yuan Zhao, Hui-Sheng Wu et al.
· Frontiers in Immunology · 0 citations