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Chunping Tang

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Open access Aug 2026

A bitter melon natural compound ameliorates the myotonic dystrophy type 1 skeletal muscle phenotype in a sex-specific manner

Results indicate that sustained AMPK activation with BMC-25 confers multifaceted benefits to DM1 skeletal muscle by improving core DM1 pathogenic features in a sex-dependent manner, and highlights the potential of natural compounds like BMCs as novel, promising and accessible therapeutics for the DM1 muscle pathology.

Shatha A. Atieh, Chimène Fahmi, Jia Liu et al. · 0 citations