METTL3 Increases Temozolomide Resistance in MGMT‐Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A‐IGF2BP2‐Dependent Manner
ABSTRACT Aims We examined whether chromobox protein 5 (CBX5) contributes to temozolomide (TMZ) resistance in O6‐methylguanine‐DNA methyltransferase (MGMT)‐negative glioblastoma (GBM) and whether it is regulated by methyltransferase‐like 3 (METTL3)‐dependent N6‐methyladenosine (m6A) and insulin‐like growth factor 2 mRNA...