Open access
Aug 2026
A phosphorylation switch governs KIF11's mechanical output during mitosis.
The kinesin-5 motor protein KIF11 is crucial for mitotic spindle assembly, driving the separation of spindle poles through microtubule sliding. Src-family kinases phosphorylate KIF11 at multiple tyrosine residues within its motor domain, but the mechanistic consequences of these modifications remain unclear. Here, we d...
A. Šemić, Babu J. N. Reddy, Joseph M. Muretta et al.
· Proceedings of the National... · 0 citations