Author

Claire Kokontis

3 papers indexed here

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Open access Sep 2026

A tripartite mechanism licenses RNA polymerase import into the phage nucleus

Nucleus-forming jumbo phages import a phage-encoded non-virion RNA polymerase (nvRNAP) into a proteinaceous nucleus, but how it is selected for import is unknown. Here, we identify an import pathway that couples nvRNAP subunit interactions with phage-encoded import factors. Maximal nvRNAP import requires a novel factor...

Claire Y. Kokontis, Deepto Mozumdar, Daphne F. Chen et al. · bioRxiv · 0 citations

Open access Jul 2026

Bacteriophage genome-wide transposon mutagenesis

Together, phage TnSeq is a scalable technology that can identify essential phage genes, generate knockouts in all non-essential genes, and sensitively assign the quantitative fitness contributions of every gene in parallel.

A. Chan, Wearn-Xin Yee, Deepto Mozumdar et al. · Cell · 2 citations

Jul 2026

Characterizing Import of RNA Polymerase into a Phage Nucleus 2310316

This work investigated how the ϕKZ-encoded non-virion RNA polymerase (nvRNAP) is selectively imported and discovered that Imp7 does not directly bind to nvRNAP in vitro, suggesting multiple potential models for nvRNAP import.

Iris Zheng, J. Bondy-Denomy, Daphne F. Chen et al. · Journal of Immunology · 0 citations